DIRECT COOMBS TEST

The direct Coombs test, also known as the direct antiglobulin test (DAT), detects the presence of antibodies or complement proteins attached to the surface of red blood cells. This test is used to diagnose hemolytic anemia, a condition where red blood cells are destroyed prematurely. A positive direct Coombs test indicates an immune-mediated cause of hemolysis, such as autoimmune hemolytic anemia, hemolytic disease of the newborn, or transfusion reactions. The test is essential for identifying the underlying cause of hemolysis, guiding treatment decisions, and preventing complications associated with red blood cell destruction.