ANTI SCL – 70 ANTIBODY

The anti-Scl-70 antibody test detects autoantibodies against topoisomerase I, an enzyme involved in DNA replication. This test is primarily used to diagnose systemic sclerosis (scleroderma), an autoimmune disease characterized by skin thickening and fibrosis of internal organs. Elevated levels of anti-Scl-70 antibodies are associated with a higher risk of severe disease and internal organ involvement in systemic sclerosis. The test helps confirm the diagnosis, assess disease severity, and guide treatment decisions. It is crucial for early detection and management of systemic sclerosis, improving patient outcomes and quality of life.